When the Mayor finds the deed to Monster Isle the monsters move to Townsville causing havoc between monsters and humans.

After witnessing a crime, Talking Dog stays at the Powerpuff Girls house for a while as part of a witness protection program.

A medium named Madame Argentina, and her side-kick, Fred the duck (he really is a duck) attempt to steal money from Townsville's citizens by offering to contact a dead relative for them.

Professor Utonium is hosting a party for all the rich and famous people in Townsville, so Bubbles makes sure that she is the most beautiful of the girls by continually grooming herself. While doing this, she notices one of Octi's legs poking out from under the girls' bed, so she goes to pick him up to find that all that's there is one of Octi's legs! After waking up from the shock, she vows to exact revenge on the person who 'killed' Octi.

When the Mayor gets a craving for toast he discovers his toaster is broken so he gives it to the Professor to fix, but he accidentally discovers the Professor's secret stash of chemical X which the Mayor uses as a hair growth formula.

After stealing a tangerine (orange) and watching it split up into different pieces the Amoeba Boys learn how to multiply and make duplicates of themselves.

The girls realize that the Professor is tired after preparing for his dissertation tomorrow, so when a burglar new to Townsville tries to rob them the girls try to stop him without waking up the Professor.

The Professor tries to figure out just what kind of species Fuzzy Lumpkins is, but when he accidentally gets covered in mud and flowers it makes him look like a Lumpkin which Fuzzy falls in love with and tries to marry.

When the Powerpuff Girls try to stop Mojo from doing a crime an animal activist group comes to his rescue protesting that the Powerpuff Girls can't harm him because he's an endangered animal.

When Ms. Keane gets sick she hires a substitute teacher named Mr.Green to run the class in her absence. Unfortunately because of his monstrous appearance the girls assume he's a bad guy and try to save their classmates from him.

Him is sick and tired of all the villains (including himself) failing in their never-ending plot to destroy the Powerpuff Girls, so he brings the Rowdyruff Boys back to life and stronger than ever.

In this musical, the girls are outmatched by Townsville's villains. They turn to Gnomey to bring peace to Townsville in exchange for their powers, but, when the city falls under the rule of Communism, it's up to the girls to stop him.

The girls wake up to discover their bed is wet. Blossom, Bubbles, and Buttercup all deny the incident, but they still wonder who did it. This destroys their confidence.

Princess interrupts a battle between the Powerpuff Girls and the Rowdyruff Boys. She tries to join the Rowdyruff Boys but they reject her, so out of pity the girls let Princess become a Powerpuff Girl.

The owner of the Townsville Museum accidentally thaws out a prehistoric caveman criminal that was frozen in a block of ice.

While cleaning out their closet the Powerpuff Girls reminisce on all the adventures they've had over the years.

After the Professor lies to the girls to avoid spending time with them a little white lie monster develops.

When Ms. Keane gets sick she hires a substitute teacher named Mr.Green to run the class in her absence. Unfortunately because of his monstrous appearance the girls assume he's a bad guy and try to save their classmates from him.

He is sick and tired of all the villains (including himself) failing in their never-ending plot to destroy the Powerpuff Girls, so he brings the Rowdyruff Boys back to life and stronger than ever.

When and organization called Parents Against Powerpuffs tell the Girls that their super-heroics are becoming too imitable for children, the Girls must hold back on fighting crime.

When Bubbles overhears the Professor saying some bad words, the Girls add a whole new slew of adjectives to their vocabulary.

When the Girls and the Gangreen Gang discover a destructo ray for sale at Mojo's Yard Sale, each team sets out to see who can earn the most money and buy it first.

The Professor tries to teach the girls all about the history of silent movies and how they're much better than the movies of today by taking them to one.

A new group of criminals, which is a group of cute little animals robs Townsville blind. The girls try to stop them, but because of their innocent looks the animal criminals have the advantage.