Uncle Eddie helps Rich and Seth make a plan to complete Santanico's revenge. Meanwhile, Freddie and Kate encounter an unexpected foe following Malvado's attack.

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Santanico confronts Malvado with Seth's help; Richie and Kate must stop Carlos and Scott from overturning the ancient prophecy and taking control of a powerful evil.

Seth and Santanico clash with Richie over his betrayal, while Carlos and Scott aim to take Malvado’s empire and unleash culebra frenzy on the world.