A bullet that was meant for Reno critically injured his girlfriend Valerie instead. After spending months in coma, she is finally released from her suffering. The criminal lieutenant Donald "Dutch" Dixon places a trap for Reno: He lets spreads the news that Valerie is healed.

Reno helps a woman with a flat tire in the desert. Soon after that the woman is found dead in her home.

Reno Raines is about to arrest the gangster franc sand when he becomes a witness, as a small Japanese girl is kidnapped.

Lieutenant Dixon and Frank Bickford think of a plan to finally capture Reno: They release a criminal Tommy, who looks just like Reno.

Joe Cortez had sworn revenge with his arrest. He breaks out of prison and procures himself weapons and money.

Reno is to snatch in a the gangster Dad Meecham and his three sons. While a brawl in the Saloon the sons become arrested, Meecham however can escape.

Reno is to bring Amber Dane, a Hollywood Starlet, before court. Reason: Amber allegedly killed her friend five years before .

Reno helps out a man being attacked in the middle of the road. The man takes Reno home with him to Second Chance Farms: a place where ex-criminals who want to begin a new life are able to work.

The daughter of Reno's loyal long-time friend Assistant D. A. Wells begins going on a downhill spiral, entering a life of drug addiction. Upon further investigation, Reno and Cheyenne discover there is much more to this family tragedy than originally thought. They soon uncover a rather elaborate scheme involving black market drugs, a touring rock band, and a corrupt band manager who plans to use the girl to leverage Wells into dropping the impending case against her brother, a notorious drug dealer.

Reno receives a video tape as proof that his estranged brother Mitch is still alive, despite being declared dead in Vietnam by the military many years prior. The video tape depicts Mitch competing in a rather sketchy underground cage fighting tournament. Reno decides to enter this strange underground world and investigate his brother's disappearance by posing as one of the fighters. He soon discovers that his brother has been brainwashed, and rescuing him from this dangerous and barbaric lifestyle will not be quite as easy as he once thought.

After having some success in the preliminary rounds of the tournament, Reno begins to make some progress with helping his brother Mitch regain his memory. This becomes easier once he slowly starts having flashbacks of childhood memories of the two. Eventually Mitch joins Reno's side. The two bring down the entire cage fighting circus and those who conduct it, with the help of Bobby Sixkiller and a special task force.