When Dr. Alicia Seberg, a government research scientist, is exposed to a deadly toxin while at work and has only hours to live, she calls Patrick Jane and the CBI to find her murderer.

Romantic sparks begin to fly when Patrick Jane and supposed psychic Kristina Frye cross paths again during the CBI investigation into the murder of a charismatic head of a non-profit organization that fights human trafficking.

Patrick Jane and the CBI team hit the horse track when a jockey is found murdered and suspects abound.

The CBI pursues two lines of investigation when a Santa is murdered: Patrick Jane goes undercover in an AA group; and Rigsby and Van Pelt question members of an authentic Santa society. Meanwhile, following the demise of a person in custody at the CBI, J.J. LaRoche is brought in to question the team when it appears to be an inside job.

When the son of a former client from Jane's days as a psychic is kidnapped, Jane and the CBI team are asked to help find him. Meanwhile, Jane butts heads with his former client's new "spiritual advisor."

Jane and the CBI team narrow down the long list of suspects after a high-end divorce attorney, with many enemies, is killed on his speed boat. Meanwhile, Jane is questioned by Agent Darcy about whether Red John was responsible for Panzer's murder.

On the ninth anniversary of his wife and daughter's death, Jane receives a message from Red John, causing Jane to lose focus on his current case and put the investigation and his career at the CBI in jeopardy

The team investigates the kidnapping of a couple that may be the victim of mistaken identity, while Jane continues his investigation into Lorelei's whereabouts.

The team investigates the murder of a reporter who may have become too close to her story, while Jane insists on pursuing his own leads to find Lorelei.

With the final clue in hand, Jane attempts to gather the remaining Red John suspects in one place in hopes of finally revealing his identity.