After a slew of brutal slayings, District 21, led by Sergeant Hank Voight go after a Columbian drug cartel cleaning house in Chicago. They discover D’Anthony who proves to be an asset in the investigation. At District, complicated histories and unit rivalries surface which could end up costing them one of their own. Meanwhile, Rookie Kyle Ruzek is pulled from the police academy by Olinski to join the team.

Commander Perry notifies the Intelligence unit that Pulpo has been released to help track down a dangerous cartel leader. This doesn’t sit well with our team as he kidnapped one of their own and no love is lost between sides. Meanwhile, Ruzek gets some difficult news as a blast from Lindsay’s past comes back, giving us a glimpse at where she came from. Voight reminds her that she’s come too far to screw it up. At the same time we learn something about Jin that is bound to be a problem.

As the Sheldon Jin murder investigation moves forward, Voight is under close watch by Internal Affairs but he’s still in complete command of the intelligence unit. A routine undercover job becomes anything but when Voight’s SUV is T-boned while trailing an armored car carrying Ruzek. Burgess meets her new partner, Sean Roman and tension is high from the start, and she soon realizes there’s more to his story. After a long day, Lindsay pays a visit to someone she hasn’t seen in a very long time.

SVU's Benson, Fin and Amaro help with the investigation of a rape-murder that's similar to a decade-old case in New York; and, after he's questioned, a suspect warns Lindsay that the investigation could have unintended consequences.

The crossover starts on Chicago Fire S03E21 We Called Her Jellybean (I). It continues on Law & Order: Special Victims Unit S16E20 Daydream Believer (III).

When a young boy is executed, Intelligence turn to the boy's parents for information and upon further investigation, discover the father has a criminal background and was a part of a local gang.

Burgess gives chase after Roman is wounded by a hooded perp who opened fire on their patrol car and shoots who she thinks is the suspect, but no gun is found at the scene—and the person she shot is a 17-year-old honor student.

The team investigates a murder in which the victim appears to have been wearing a CPD-issued wire. Burgess works a case with a new partner. Crowley questions Lindsay about the night that Intelligence pursued Justin's killer.

When a young officer is shot dead in the lobby of an apartment building, Intelligence looks to the latest known offenders who have threatened the police. But when a second officer is killed, the team finds that they are dealing with someone who is highly trained and knowledgeable.

Olinsky's daughter remains in critical condition following a massive fire - leaving Intelligence on edge, but more determined than ever to track down the suspect. Voight opens up the case, knowing that he has Stone and his team's full support in the investigation, and all of Firehouse 51 behind him to examine potential origins of the fire.

The crossover starts on Chicago Fire S05E15 Deathtrap (I). It continues on Chicago Justice S01E01 Fake (III).