Two best friends discover a doorway leading to the hospital for super heroes.

Oliver uses his burgeoning medical skills at school when he performs CPR on a popular girl's poodle, which quickly elevates his social status much to Kaz's chagrin. When the popularity goes to his head, Kaz cuts Oliver down to size, literally, with a shrinking ray. Meanwhile, Horace cannot perform surgery on Citadel, an ailing superhero with an impenetrable metal exoskeleton, so shrunken Oliver is sent inside the hero's body to diagnose the problem.

Alan is put in charge of the hospital for a day, but he abuses his power and makes life miserable for everyone.

Kaz plans a surprise birthday party for Oliver and accidentally lets in the villain Revengeance.

Skylar introduces Kaz and Oliver to her longtime friend Experion, a cool and charming teenage superhero. But when Oliver catches Experion in an evil act, he must convince Skylar that her bestie is not as nice as he seems.

Kaz and Oliver are exhausted and stuck working the overnight shift during a lunar eclipse, when it is rumored that the freakiest patients come to the hospital. When Neocortex checks in with an illness that unintentionally traps people in their worst nightmares, Kaz and Oliver desperately try to stay awake and figure out how to save everyone from their nightmares.

Wallace uses an optical image replicator to turn Clyde into an identical look-alike of Kaz in hopes that the disguised Clyde will trick Oliver into revealing the secret location of Mighty Med.

Oliver and Skylar pet sit Horace's shark that is kept in the aquatic wing of the hospital. When Oliver feeds the shark the wrong food, the shark evolves into a man-shark.

It’s been a year since Skylar lost her powers, so Oliver and Kaz decide to throw her a party to celebrate their one-year anniversary of friendship. But when they learn that Skylar is in danger of losing her powers permanently, Oliver and Kaz set out to get them back.

It’s been a year since Skylar lost her powers, so Oliver and Kaz decide to throw her a party to celebrate their one-year anniversary of friendship. But when they learn that Skylar is in danger of losing her powers permanently, Oliver and Kaz set out to get them back.

Kaz and Oliver know that Skylar is evil, but Skylar doesn't know they suspect anything. They need to keep it that way or she may turn on them as well. They brace themselves until Skylar asks Oliver to the school dance that night.

Oliver is in charge of rehabilitating Wallace and Clyde since he believes they still have good left in them. Meanwhile, Kaz tries to give himself super powers with Skylar's help.