Claire and Jamie leave Scotland, sailing to the West Indies on an urgent quest. But when the superstitious crew looks for someone to blame after a string of bad luck, rescue comes from an unlikely source.

Claire races to discover the source of an epidemic aboard a disease-stricken ship before hundreds of sailors die. And as Jamie locks horns with Captain Raines, Fergus finds himself torn between loyalty and love.

After making a leap of faith, Claire washes up on an island where survival is her only option. Navigating treacherous waters crippled the Artemis, so Jamie devises a joyful moment for his crew in the midst of setbacks.

The Artemis finally reaches Jamaica bringing Jamie and Claire much closer to their goal. During a ball on the island, the Frasers encounter old allies, as well as former adversaries who threaten to derail their mission.

Claire plays a game of cat and mouse with an old adversary as she searches for young Ian. The Frasers race through the jungles of Jamaica to prevent the unthinkable.