Sarah, a streetwise hustler on the run from a lifetime of bad decisions, witnesses the suicide of a stranger who looks just like her. Sarah assumes her identity, hoping that cleaning out the dead woman’s bank account will solve all of her problems. Instead, the street smart chameleon is thrust headlong into a kaleidoscopic mystery. After taking on the new identity, Sarah quickly finds herself caught in the middle of a deadly conspiracy and must race to find answers.

With a body in her car and nowhere to turn, Sarah is forced to continue her con and earn “Beth” a second chance on the force. But with a killer on her tail, her only hope of finding answers lies with another apparent ‘identical,’ Alison.

Rocked by the revelation that she and her fellow "Orphans" are clones, Sarah just wants to get her hands on the money and skip town. But Sarah’s fake detective ruse stretches thin when the cops find the body she buried and assign “Beth” to the case. As Sarah closes in on the killer, the hunter becomes the hunted.

Sarah realizes that the Orphans’ survival is going to take more than police work. But tracking the killer threatens Sarah’s long awaited reunion with her daughter, Kira. As Sarah gets closer to the killer, the killer gets closer to the truth – the ensuing showdown threatens to expose her ruse as a cop.

When terrifying evidence suggests the Orphans are part of a sinister ongoing experiment, Sarah’s suspicions turn to Paul, Beth’s boyfriend. But her probing inadvertently triggers Paul’s own investigation, bringing him dangerously close to the truth. Meanwhile, paranoid Alison piles on a whole new level of complication.

Sarah’s hunt for answers is interrupted by a trip to the suburbs. Alison’s paranoia has boiled over, putting all the Orphans at risk. But when Sarah, Alison and Beth’s worlds dangerously collide, Sarah must decide who to trust with her secret.

With Paul missing, Sarah is forced to confront the conspiracy head on. But when Paul learns Sarah has kept essential information from him, the fragile trust between them threatens to shatter. Meanwhile, Cosima grows closer to Delphine and the dangerously fascinating Dr. Leekie.

Sarah's actions pit the Orphans against each other as she tries to plan her next move. As Paul tries desperately to cover up Sarah’s existence, Alison takes vengeance on her suspected monitor, which could cost her everything she holds dear.

After Kira’s life is threatened, Sarah is on the warpath, but Dr. Leekie makes her think twice about her plans for revenge. Meanwhile, Cosima faces the truth about Delphine, forcing her to choose sides. Now, it’s up to Sarah to decide the killer’s fate, but the truth about where Sarah came from changes everything.

Sarah’s last chance to bring her nemesis back to sanity slips away as Art intervenes to get answers of his own. Meanwhile, the Orphans must decide whether to make peace with their creators, as Sarah is forced into a deadly confrontation with their enemy.

Sarah is out of options, on the run, and pursued by deadly adversaries. Desperate to find her daughter Kira, Sarah suspects ruthless pro-clone Rachel is behind her daughter’s disappearance and sparks an all out war against her. Alison and Donnie attend the funeral of her fallen friend, Aynsley, causing Alison to sink into guilt and despair. Cosima is faced with a perplexing decision that may have dire consequences.

While Alison struggles with Aynsley's death and Cosima grapples with the worsening symptoms of her mysterious sickness, Sarah enlists Art’s help to find Kira and is shocked when she learns where the trail leads.

After hitting the road with Felix, Sarah is forced to turn to a ghost from her past - an old flame named Cal Morrison. When their brief respite is brutally shattered, Sarah realizes that no matter how far she runs, it will never be far enough.

Sarah comes home looking for answers, and with the help of Cosima, they begin digging into the origins of the clone experiment. The hunt for answers takes her right into the belly of the beast, but getting out could cost her more than she knows.

Rachel goes on the warpath, lashing out at Sarah's nearest and dearest. While she tries to keep her loved ones safe, an unexpected visitor threatens to derail Sarah's plans.

Sarah joins forces with an unlikely and untrustworthy ally, following a trail of clues that she hopes will lead her to the origins of the clone experiment. Cosima and Delphine make a discovery that could prove to be the key to treating her illness. Alison finds herself in unsavory company at rehab.

When a rehab confidante betrays Alison and threatens to expose the truth about Aynsley’s death, she goes into free fall on the eve of Family Day. With Donnie and the kids set to visit, it’s all clones on deck to contain the fallout.

A new player in the clone conspiracy turns up at Felix’s door, sending him into crisis mode. With Cosima running out of options, Sarah struggles with the decision to surrender a crucial piece of leverage and make a deal with Dyad.

Cosima takes a turn for the worse, forcing Sarah to take desperate action which results in tragic consequences for those she loves. The Proletheans set their ultimate plan in motion, while Alison and Donnie tangle with the law.

The war with Dyad is all but lost when Rachel’s latest ploy forces a broken Sarah to concede. The Clone Club springs into action, uniting in a reckless gambit to save Sarah. As they fight to gain their freedom, Sarah encounters a new ally and uncovers a terrifying new dimension to the conspiracy.

Sarah is deeply wounded and struggling to stay alive on the Island. Driven deep into its forest by Neolutionists and worse, she strives to make it far enough to rescue Cosima. Meanwhile, a recovering Cosima reunites with Delphine, but there's way more going on on this Island than Cosima imagined and Delphine can't give her all the answers she needs. What is clear is that Rachel is now firmly in charge as the right-hand of the 170-year-old founder of Neolution, P. T. Westmorland. Back home, Neolution puts the screws to Alison and Donnie in their hunt for Helena. The sestras couldn't be further apart when they need most to be together.

Captured by Neolution Sarah receives a damning ultimatum from Rachel: come into the fold, or lose your family. Her decision causes a clash with Kira who begins exploring her own maturity. Meanwhile, Ferdinand struggles to get a handle on Rachel's new velvet glove mandate in pursuit of the clones. With Neolutionists and Ferdinand watching their every move, Felix brings an old ally into the mix to help his family get Kira to safety. On the Island, Cosima struggles to comprehend the reality of the Neolution myth made real.

Stuck on the sidelines with Neolutionists crawling all over her home, Alison seeks to return to her community center, but Bailey Downs has moved on from her. As she flounders to take back some semblance of control, the ghost of friendships' past rears its handsome head. Art and his new partner show up at the Hendrix residence to continue their search for Helena, forcing Art to make a difficult moral judgement.

Following up on intel from a mysterious source, Mrs. S heads on the road with Sarah to investigate a lead on a Neolution defector. Meanwhile, an unexpected reunion takes place on the island, while Cosima's research leads her to a discovery more terrible than she could have ever imagined. As more pieces slide into place, the puzzle only seems to become more complicated.

While Sarah and Kira spend some well-needed bonding time at home, secrets are unlocked about Kira’s special gifts that are surprisingly linked to the island’s creature. Meanwhile, Cosima joins Delphine at the mansion for a twisted family dinner, causing a dangerous showdown with the Neolution patriarch.

Cosima is forced into an alliance when an old enemy returns to the island, accelerating P. T. Westmorland's sinister agenda. Meanwhile, on the mainland, Krystal stumbles onto a vital clue to the Neolution endgame. Sarah and Mrs. S’s research into Neolution's corporate ties leads to the cosmetics industry and an inevitable cross with Krystal Goderitch. But before Sarah can dig deeper, Krystal hijacks the investigation.

As P. T. Westmorland demands a more aggressive action on Kira, and Sarah fights to save her daughter, Rachel discovers a dark secret that makes her question her place within Neolution. Meanwhile, Cosima has returned with a vital clue to Westmorland's true identity.

Mrs. S orders the sisters to take a night off from sleuthing to celebrate Felix's art opening. But while Felix attempts to impress a famous gallerist with the help of his sestras, Sarah remains on edge with a nagging suspicion that S is hiding something. Meanwhile, wounded and desperate, Rachel reunites with an old ally, but their plans for revenge on Neolution put Clone Club in the line of fire.

A devastating loss is eclipsed when word reaches Sarah that Helena has been kidnapped. Clone Club bands together in a race against time, determined to find her before she has her babies. And with time running out, Sarah is forced into action in a last-ditch effort to save her sestra.

With Helena forced to take shelter behind enemy lines, it’s a bloody last stand for survival as Sarah and Art struggle to protect her, and end the siege on the sestras once and for all.