Growing up in a small Texas town, Misti Mayo and Christine Smith share everything: clothes, music, even teen pregnancy. But a move to the big city introduces them to a new lifestyle and a new group of friends. They find themselves in a spiral of bad decisions and escalating violence. With their backs against the wall, each of the girls has to choose between herself... and her best friend.

Butch Pratt and Ed Swiger meet as freshmen at an idyllic college campus in western Pennsylvania. They're fast friends, fraternity brothers, and ultimately college roommates. Both are on the way to postgraduate studies and glowing careers. But a botched prank against their own fraternity suddenly puts the law on their tails. And with their futures at stake, one of them decides that success is worth killing for.

Can we ever escape our past? An organic farmer (Patrick Drum) meets a lumber mill worker (Gary Blanton) in Washington’s Olympic Peninsula. They become close friends, and when Gary has to move out of his house, Patrick invites him to share his cabin in the woods. But one of them is hiding a dark secret. And when the other finds out, it begins a spiral of anger and vengeance… leading to a killing spree and an intensive manhunt. With two bodies already found, police race to find the suspect before he kills again.

When two young mothers meet by accident, they seem destined to become best friends. Jamie Dennis is an aspiring writer who spends hours honing her craft. Anne Camp loves playing with Jamie’s children, and she offers to be their babysitter. But this friendship is heading for trouble. Jamie has money problems and needs a quick way to pay the bills. Anne is in a bitter custody battle for her own daughter. Both women will have to make a terrible choice: to save your family, would you sacrifice your best friend?

Dean Allen is a clean-cut carpenter in east Texas, a young man who always follows the rules. Dean befriends a newcomer, Robert Pogue, a butcher who never met a rule he couldn’t break. Dean is drawn to Robert’s fun-loving nature, and the two become best friends. Although only 17, Dean meets and marries Janice, who is five years his senior. But when Janice begins an affair with Robert, the two best friends turn on each other–a showdown that will end in gruesome death.

Lula Young and Linda Leedom seem like typical moms. They live on a quiet suburban street, raising their families side by side. Lula is a homemaker who volunteers at the fire department, and Linda is a former nurse with a home business as an accountant. Through sickness and heartbreak, Lula and Linda are best friends and perfect neighbors. But looks can be deceiving. To make her dreams come true, one of them will do anything: fraud, arson… even murder.

Whoever said there's honor among thieves... never met this group of best friends. Michael Falco, Gary Evans, and Tim Rysedorph all come from working-class South Troy, NY. Friends since childhood, they dream of careers in music and the arts. But to survive in this Rust Belt town, they turn to small-time criminal activity. As the crimes get bigger, so do the stakes. The police are closing in, and one of them turns on his friends, murdering them one by one. Can he be stopped before he kills them all?

Alabama party boys and best friends Butch Hampel and Richard Terry meet while working at the local paper mill. The two are inseparable bachelors and roommates living the good life, until a woman comes between them. When one best friend falls for the other man's wife, all bets are off. It's a violation of an age-old code, a code their friends call "Dude Law." But will this be a crime of passion, or a crime of jealousy?