Connor suspects terrorism when two congressmen and an officer fall prey to an unknown disease. However, when the leader of a prostitution ring becomes ill with the same symptoms, an unknown STD becomes the suspected agent. Now it is a race against the clock, and their pesky boss, Dr. Ewing, to find a call girl who may be the source of this deadly outbreak.

Connor and Powell must travel to a small Mexican town after an earthquake strikes, trapping Natalie, Eva, and Miles. Only when they go after Miles, who was trapped in the church Mission La Roca, they are captured by insurgents.

The team figures out that they are dealing with bacterial meningitis, and the only thing that makes their day worse is a corrupt politician who steals the medicine and holds it at ransom. Elsewhere, the people at Mission La Roca (Miles, Connor, Powell, Nestor, Juan, Kris, and Baracas) make it out before the church collapses, and take the sick ones off to the hospital for treatment.