A woman involved in a car accident is concerned about her dog so John agrees to take care it, which complicates his life. At the hospital, doctors treat a girl who has difficulty breathing and a man who appears to be drunk. When a man has chest pains at a party, his guests think he is joking. The paramedics rescue an injured hunter.

John keeps losing at cards and being stuck with doing the dishes at the station, so he creates his own card game. Roy talks down a boy in a plane after the pilot (his father) has a heart attack. The paramedics respond to an attempted suicide, an overturned truck and a teenage overdose victim.

John is convinced that weird things will happen on their shift: a parachutist lands in a tree, an obese man collapses while jogging, an 80-year old woman breaks her ankle while dancing, a man can't stop the hiccups, a boy tries to cryogenically freeze himself, an golfer is bitten by a snake, a prostitute brings in a customer suffering from chest pains, and John is injured during the rescue of a drunk driver.

John misses the end of an Adam-12 episode. A jewel thief is trapped in an air-conditioning duct. Two battered men continue their brawl in the hospital. A man ruins his cast by going surfing. Dr. Brackett treats a woman with a neurological disorder. Radioactivity impedes the rescue of a lab worker.

A sick lady with a monkey provides the key to a mysterious, highly contagious, and deadly virus that strikes both Dr. Brackett and John. Meanwhile, the firemen rescue a boy from a treehouse and a man from a scaffold.

Roy has an argument with his wife and Johnny tries to help. The firemen rescue a man from precarious auto wreck. A brilliant doctor's erratic behavior causes concern at the hospital. Doctors diagnose a woman's heart condition. Paramedics rescue a dog from a roof and two children lost in a rapidly flooding storm drain.