Cranky old Daniel Mueller fences in a pasture that's a shortcut the kids use going and coming to school and the boys want revenge, but Lassie is privy to his gentle side. Then one night the collie discovers Mueller seriously ill.

After visiting to Timothy Powell's summer home, Jeff is envious of the wonderful things he saw at the wealthy Powells and turns up his nose at the farm and Porky. So when the Powells go away for the weekend, Ellen has Timmy stay with the Millers.When Timothy falls seriously ill, however, it is Ellen's unwavering care that brings about his recovery, and Jeff realizes that money isn't everything and Jeff finds out the boy thinks he's the lucky one.

With Jeff at the dentist, Timmy and Gramps go out to pick huckleberries for pies for the church supper. Timmy thinks Gramps is ill when he naps after berrying, but it's Timmy who must be rescued after eating nightshade berries.

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Paul, Timmy, and Lassie are stranded on a deserted road when Paul realizes Timmy is becoming seriously ill. Lassie must risk her life to bring help to the sick child.

Timmy is stricken with severe stomach cramps and keeps calling out for Lassie.

After a local farmer dies on the way to the Capitol City hospital, fifty miles away, the Martins spearhead a plan to start a community hospital, but a prominent farmer known as a skinflint refuses his approval.