The newest nurse, Julie, doesn't exactly inspire her co-workers with confidence. Meanwhile, Sandy is shocked to learn her ex-husband is planning to marry a very young patient.

A mentally unstable patient (Larry Linville) is told that he has to cut sulfites out of his diet, so he responds by taking the staff hostage at gunpoint... Which doesn't sit well with Sandy, who was supposed to be off on a big date.

Sandy's mother arrives for a visit and immediately starts to complain; Gina is upset to learn Hank is dating other women.

Paco becomes indebted to a mob boss; Gina tries to make Hank jealous by dating another man, unaware that he is gay.

When a patient is killed by an ambulance, Annie begins to question her faith in God.

A former child star, Chet ""Poofie"" McGuire (Stephen Furst), comes to the hospital to research his new role for the sitcom ""Poofie McGuire, Nurse for Hire."" Greg's star-struck, but everyone else is annoyed – particularly Annie, who has to take Chet on rounds with her. But Chet's attitude changes when he witnesses the staff revive a dying man. Meanwhile, Julie goes on a ""holy quest"" to track down the brother of that dying man and Dr. Riskin fends off an obnoxious mother who's giving her son high blood-pressure.

The entire staff is pulled in to cover a double-shift during the full moon. Julie tells her co-workers about her grandmother's theory on the full moon – how it's a chance to make up for missed love opportunities. Sandy finds herself falling for Charlie Deitz. Paco decides that he's going to ask out Gina. Hank wants to ask out a slut… but he changes his tune when Gina attacks him and sticks her tongue down his throat in the elevator. A hernia-surgery patient makes repeated attempts at escaping; a former astronaut arrives with a bump on the head; and Blanche Devereaux tracks down Dr. Riskin because she can't get a man to bed her.

When a patient comes out of a 38-year coma, Dr. Riskin shocks the staff by telling them she was once engaged to the man, and that they had a son.

Gina realizes Hank is still carryin a torch for his ex-wife; Greg is trapped in the elevator with a cannibal.