Samantha arrives at Charles University and she reveals that she can not afford a meal plan. She meets her new love interest, Devon Sylver, and just as things start to look good for Samantha, it all comes crashing down when something tragic happens. Meanwhile, actress Dawn Vargas arrives at Charles University in search for a normal life but she gets drunk at the local University hotspot, a club named Colony, and Trent, the bartender, decides to help her.

After Samantha complains to Darryl about the noise from her roommate, Kathryn, in her dorm room, Darryl imposes an eviction bylaw to anyone who makes excessive noise in the dormitory. The other dormitory students blame Samantha for the bylaw despite her protest that she did not mean for this to happen. In hopes of winning back the hearts of the students in the dormitory, Samantha decides to break the rules and plan a party. Meanwhile, Kathryn decides to plan her own party.

Samantha attends the club fair with her new friend Dawn and quickly decides she wants to join a sorority. However, there is only one spot available and her competition becomes Kathryn. Kathryn, knowing that Samantha has a better chance of getting in the exclusive sorority than she does, decides to dig up some dirt on Samantha's life. While at Colony, Sam finds Kathryn making out with Beau, the boyfriend of the sorority's leader, Sloane. After Sloane confronts Sam about the dirt dug up by Kathryn, Sam decides to tells Sloane about Kathryn and Beau. However, Sloane is not impressed by Samantha's intentions. Meanwhile, Sam and Devon's relationship begins to blossom, but it does not last long.

Samantha and Noah's business teacher gives them a huge assignment and the students with the lowest marks from the assignment will be forced to drop the course due to over enrollment. Sam and Noah decide to partner up for their business assignment, only to learn they must sell calendars plastered with pictures of Devon. With Devon and Sam's relationship still on the rocks, Sam builds up the courage to ask Devon for help.

Samantha and Devon get back together and when all the pieces seem all to fall in place, a new problem ensues. Devon and Sam decide to go to the Halloween party at Colony dressed as ketchup and mustard. Everything is fine before Cynthia shows up drunk and dressed as relish. Sam becomes torn between spending time with her new boyfriend or Cynthia. When Sam finally confronts Cynthia, she does something shocking.

Samantha becomes stressed over her upcoming exams and temporarily moves in with Dorothy to get some quiet study time. Sam visits Cynthia in the hospital and is determined to find out what is wrong with her. Meanwhile, Dawn's diva attitude causes the entire cast and crew of "Macbeth" to quit and Sam discovers Cynthia's secret.