Dr. Catherine Black reveals to her therapist Dr. Hartramph that she's feeling empowered, unstoppable, and at the top of her game. This world renowned neurologist has a secret that is becoming more and more difficult to control--she’s bi-polar. At the state of the art facility where she works, Catherine has an insight to her patients that no one else has, allowing her to communicate with them on a different level. Catherine is introduced to a mysterious new man named Dr. Ian Bickman. She's met her match when this boisterous new colleague joins the staff at The Cube. At home, Catherine's boyfriend is pressuring her to marry him, but what would he do if he knew that there's another side to her that’s not easily controlled.

Dr. Black's team of fourth year medical students try to determine why a young nanny is suffering from hallucinations of her head exploding. Will and Catherine struggle to get their relationship back on track after she reveals that she cheated on him during a manic episode? After the chief of neurosurgery suffers a seizure during surgery, the Cube’s medical director calls a meeting to announce that any doctors suffering from medical conditions that could harm patients must come forward.

Catherine and Joshua have different ideas about how the past unfolded after their father made the decision to leave them. Hunter Black is ready to reconnect, though Catherine is reluctant to allow him back into her life. Meanwhile, a decorated soldier is struggling with a war wound that has left him miserable. Another patient is admitted to the Cube with macular degeneration after she falls off the side of a mountain. To her surprise, she begins to see vibrant visions of snow leopards and landscapes that she could have never imagined. Elsewhere, Will discovers that he can't get rid of Delilah without risk of losing his restaurant.