A serial killer is on the loose and Sergeant Doug Niemeier has the unenviable task of hunting him down. The question is, will he manage to find the killer before more people lose their lives?

Homicide Sergeant Joe Schillaci and his squad must solve a murder of an innocent college student during a hectic Memorial Day weekend; Sergeant Carlos De Los Santos and his team tackle the murder of a doctor found hogtied in his house and learn that the key to the case may lie with the voodoo-like Santeria shrines found at the crime scene.

Sergeant Altarr Williams goes on an adrenaline-charged hunt for a mysterious van seen leaving the scene of a brutal murder; Detective Emiliano Tamayo and his team must identify a nameless victim gunned down in Little Havana; the case takes a shocking turn when they discover the victim's background.

In Kansas City, KS, Capt. John Cosgrove and his team of homicide detectives must track down a man suspected of beating his best friend to death with a cinder block--before he can flee the country; Dets. Greg Lawson and Mike York are hot on the trail of their murder suspect they know only as "Teeth.

Detective Mike Polk and his team painstakingly reconstruct the final hours of a man found dead hogtied in a hotel room; Detective Tim Angell and his partners find a nameless man beaten to death floating in a creek. They must race to identify the victim and find anyone who may have known him.

With Hurricane Jeanne threatening, Sergeant Joe Schillaci and Detective Olga Rome must solve the murder of the owner of a popular strip club. The club's surveillance video reveals three men ambushing the victim. Schillaci and Rome soon realize this was an inside job-- the victim was betrayed by one of his workers.

Detectives investigate the discovery of a murder victim along the highway and the murder of a Mexican migrant worker.

At a housing area called "The Grove," fifteen shots are fired at a car: three of the four men inside are shot, one fatally. Sgt. Joe Schillaci is tasked with solving this case; he decides to "force" the drug dealers in the area to help, by turning up the heat in the area. Tips flood in! In "Showstopper," Det. Emillano Tamayo and his rookie partner Ruggerio are assigned to a case of the death of a local singer. Robbery seems to be the motive; even his car is gone. The only clue? A missing cell phone which has been used since the murder. Finding it will lead to the killer.

Detective Dave Barnes must track down desperate lovers on the lam to solve a savage shotgun murder; Detective Tom Froelick and his team find a body of a woman in a wooded area and learn that she was last seen alive with a mysterious stranger.

Soon after discovering a bullet-ridden body in Overtown, Sergeant Joe Schillaci learns the murder may spark a bloody turf war between rival heroin dealers in the neighborhood. Schillaci realizes to prevent further bloodshed, he must infiltrate the world of heroin dealers and get them to reveal the killer's identity.

Detectives Randy Loboda and Phil Harding find two bodies, burned up, in the opposite side of town on the same night. Loboda's investigation leads to a motel where they find a bloody room, the possible murder scene, while Harding learns the two victims may have been killed by the same killer; Sergeant Joe Schillaci finds a man's body, a victim of an apparent suicide, but his investigation takes a twist when he discovers signs of a struggle. Schillaci soon learns the man was seen with a mysterious woman only hours before his death, but the woman has disappeared. She may be the killer or yet another victim.

Detective Ervens Ford and his team learn the suspected killer of a young man shot to death in Little Haiti is a member of a notorious gang. The team must hunt him down before he flees the country; when two teenagers are brutally gunned down in the Pork-n-Beans project, Sergeant Pepi Granado and Detective Freddy Ponce learn there's a witness who saw the murders go down.

A man is found murdered in his bed and the killer might be working for a traveling carnival.