Catherine Rawlins, a female victim of Janos Skorzeny (the vampire from the original Night Stalker TV movie) is accidentally resurrected outside Las Vegas, and makes her way to Los Angeles. She takes up her old profession of call girl and Carl wrangles an assignment there to investigate.

A series of mysterious deaths plague the life of conductor Ryder Bond. In each case, the victim is incinerated by supernaturally hot flames. As Kolchak investigates, he finds out that an arsonist, Frankie Markoff, was a fan of Bond's, and was killed in a penny arcade. His funeral procession crossed Bond's car, allowing the spirit to become a ""doppelganger"" and try to take over Bond's life. Each victim was burned to death when they fell asleep, and if Bond goes to sleep the doppelganger will take him over for good. Fighting sleep himself, Kolchak must exhume Markoff's body and reunite it with his restless spirit before he too bursts into flame.

A fashion industry spy is thrown to his death from a room filled with nothing but mannequins as Carl looks on from the street below. This is but the first in a series of strange murders that point to a supernatural origin: apparently Madame Trevi, a leading designer in the fashion industry, is using witchcraft to stop those who oppose her. With the aid of a witches' coven, Carl is pointed to the source of Trevi's power and destroys it, only to find who the witch truly is. Armed with a mojo bag, Carl must confront the witch and publicly accuse her to strip her of her powers.

On a college campus, young men are dying of heart attacks. According to witnesses, they are last seen with young women who apparently died shortly before meeting the men. When Kolchak investigates, he finds that the men were associated with Professor Spate, who is researching an ancient Middle East tablet, and that a series of similar deaths plagued his expedition to recover the tablet. The tablet is tied to a supernatural creature known as a succubus, who possesses young women at the moment of their death and then reveals her true visage to men, frightening them to death and feeding upon their energies. Kolchak must destroy the tablet to destroy the succubus once and for all.