A serial killer who preys on women haunts Chicago, and Kolchak comes to believe that the killer is in fact the original Jack the Ripper, a seemingly immortal killer who has killed women in many cities over the last century. The reporter must track the killer to the old house where he has taken up residence and put an end to his existence once and for all.

A bizarre alien presence invisibly sweeps through Chicago, killing a petty thief and a UFO nut. The alien or aliens have the strength of a hurricane, generate a massive electromagnetic field, steal lead and electronic equipment, and suck the bone marrow out of humans and animals alike. Kolchak must track the alien(s) from an electronics warehouse to an observatory to Lincoln Park and drive them off before they kill again. His camera seems to hold the key to the creatures' weakness, although initially Carl is wrong in guessing what the weakness is. Carl follows the aliens and manages to keep them from feeding on him before they depart once and for all.

Bernhardt Stieglitz, a NATO soldier bitten by a wolf, leaves a string of murder victims behind him. When Vincenzo is forced to abort his long-awaited vacation and report on the last cruise of an ocean liner, the USS Hanover, Carl takes his place, only to find that Stieglitz is one of the passengers on board...and the full moon is rising. Trapped aboard the liner, Kolchak must use a shotgun and silver buckshot to kill the creature once and for all.

Kolchak discovers a young rising politician, has made a deal with the Devil to murder off his competition through incidents made to look like accidents.