Out of the ashes of humanity’s nuclear war, Night Eternal has begun. Haunted by the atrocities committed by his son, Eph abandons NYC for Philadelphia. His solitude is cut short when he encounters new fighters who rekindle his drive to fight back. Tasked by Setrakian, Fet and Quinlan search for a new means of stopping the Master.

Imprisoned as a subject in a strigoi breeding program, Dutch is desperate to escape and find Setrakian. Gus recruits his cousin for the inside job that will put his gang at the top of the new world’s underground economy, but Creem is suspicious of his business partner’s ambitions.

Quinlan and Fet discover that stealing a nuclear warhead isn’t easy when they encounter an unexpected enemy. Eph and Alex concoct a new weapon to use against the strigoi. Frustrated with his seclusion, Zack discovers a love interest.

Dutch is forced to make a deal with Desai, while she plots to escape a strigoi breeding facility; Eph and Alex seek to uncover the dark secrets behind the Partnership's new plan; Gus and Creem face off against a gang encroaching on their turf.