Eph and Nora experiment on their newfound patients. Fet and Dutch grow closer as they clear out the neighborhood buildings, and Kelly begins her hunt for Zack.

Eph and Nora finally see their lethal virus in action. Fet takes the security of Red Hook into his own hands while Dutch and Setrakian set off for Staten Island to question Fitzwilliam, Palmer's former body guard.

Justine takes drastic measures to counter a surprise invasion. Nora and Fet perform a useful mission while Eph and Setrakian face off against an old foe.

Eph must choose between Zack's safety and the safety of the citizens of NYC. Meanwhile, his relationship with Nora reaches a critical impasse, and Gus and Angel assemble an unlikely gang of Sun-hunters.

Setrakian and Fet battle for possession of the Occido Lumen, and gain a surprising new ally. A massive attack imperils Eph, Nora, and Zack's escape from New York.