Setrakian anfører Eph, Fet og Nora i jagten på The Master's skjulested. Alene tilbage i pantelånerbutikken sætter Zack livet på spil for Marielas skyld.

New information from the Lumen forces Setrakian to seek help from his lifelong nemesis, Eldritch Palmer. Eph's new experiments to understand strigoi communication seemingly take him to the brink of madness while Fet is on a mission to discover strigoi movements across New York City.

Fet strikes hard at the heart of the strigoi army while Justine embarks upon a risky mission to drive the strigoi out of Manhattan once and for all. Gus and Angel fight for their lives and their freedom but are faced with a moral dilemma.