De fire overlevende begynder at udvise mærkelige symptomer, men Eph og Noras forsøg på at sætte dem i karantæne modarbejdes i takt med, at en misinformeret kampagne breder sig. I mellemtiden får Setrakian i fængslet et overraskende besøg af en gammel - en endog meget gammel - bekendt.

Imprisoned as a subject in a strigoi breeding program, Dutch is desperate to escape and find Setrakian. Gus recruits his cousin for the inside job that will put his gang at the top of the new world’s underground economy, but Creem is suspicious of his business partner’s ambitions.

Dutch is forced to make a deal with Desai, while she plots to escape a strigoi breeding facility; Eph and Alex seek to uncover the dark secrets behind the Partnership's new plan; Gus and Creem face off against a gang encroaching on their turf.

Fet and Quinlan track a convoy carrying their prized nuclear weapon; Eph and Alex search for clues to uncover the Master's plan for the fate of the human race; a familiar enemy traps Dutch, who encounters an old friend as well.