A series of bizarre killings involve murderers who have no connection to the victims. The Keeper becomes the next unwitting ""murder,"" as she is part of a insomnia-research project. The project's scientists are using the device to program their subjects to become assassins. The Keeper's sanity is threatened if she can't complete her ""assignment."" Fawkes and Hobbes eventually mange to bring in the scientists, and come up with a means to break the Keeper of the programming (by faking the death of her ""victim"") before she goes mad.

Hobbes and Darien meet with one of Hobbes' contacts to set a trap for their arch-enemy, Arnaud. Arnaud manages to escape Darien with the aid of a smoke canister, which turns out to contain a biological weapon. Darien is soon displaying flu-like illness symptoms, and is excreting black, contaminated Quicksilver. The Official and the Keeper send him to a military hospital...which Arnaud has already infiltrated. He plans to remove the Quicksilver Gland from Darien's skull via surgery, but the illness complicates matters. He must kidnap the Keeper to cure Darien so he can gain an uninfected Gland. Darien manages to escape and, overwhelmed by madness, almost kills Arnaud. The Keeper manages to stop him but Arnaud escapes. (Copyright 2002 Steve Crow)

The agents find themselves hunting for the legendary Sasquatch on an Indian reservation after two men have been killed there under mysterious circumstances.

The Official sends Eberts out with the agents to capture a computer hacker who is trying to get at the Agency’s most sensitive information.

A strange old man who has lost the ability to experience normal sensation comes to Darien in the hopes that he can lead him to his late brother, Kevin, whom he blames for doing a horrible thing to him.

Alex finally locates her missing son at a Chrysalis baby camp, only to discover that he belongs to Stark, the agency’s sinister leader.

Darien helps a young woman who seems to be haunted by a strange apparition, and she is convinced it is her mother, who had disappeared mysteriously weeks before, trying to communicate with her.

The agents are sent to capture a dangerous government assassin who is said to have switched allegiances, and Darien is stunned to discover that the man may be his own father, who has been missing for decades.

The keeper develops a way to keep Darien's invisibility static.

Darien's sudden immunity to the counteragent forces the Keeper to use an untested antidote.

Darien learns that the Keeper and the Official have been keeping antidote secrets.