Red informs the team that "The Alchemist" - a man who relies upon science to transform a person’s DNA - has been contracted to protect a well-known mob informant and his wife. As the team goes undercover to catch him, Liz finds herself on the hunt for an unlikely couple. Meanwhile Liz and Tom find themselves at another bump in their relationship and Ressler debates whether or not he should give his ex-girlfriend his blessing.

After a recent spate of abductions of babies from their mothers, Red informs Liz that the "Cyprus Agency" is the illegal adoption organization responsible. Coincidentally, Liz and Tom contemplate adoption of their own which fuels Liz to track down the organizations CEO, Owen Mallory.

Liz helps Tom adjust to the impending adoption; Red reveals a woman from his past is a target; Red convinces Liz to pull of a heist at the Syrian Embassy.

Red believes he knows who was responsible for a prominent prosecutor's 12 year disappearance; Red investigates the woman who tempts Tom.

One of Red's former associates, a crime lord, becomes the next target; Tom decides to confront Jolene.

After a cyber defense asset is stolen by a terrorist only known as Ivan, Red and Liz discover a cover-up; new evidence regarding Jolene's disappearance unravels some of the mystery surrounding Tom.