Liz's loyalties are tested as Red takes action on an operation to intercept Alexander Kirk. Meanwhile the Task Force races to find a killer who targets inventors of revolutionary technology.

When Red provides exclusive intel on an international terrorist, it puts Liz and the Task Force on a collision course with a rival unit from the CIA. Meanwhile, Red and Hawkins lay the groundwork for their new business venture, and Tom goes undercover in search of information.

As Liz and the Task Force race to stop an imminent bombing by an elusive Blacklister, Red has an encounter that will change the trajectory of his life forever.

While Red and Dembe enlist Glen's help in stacking the jury to Red's advantage for his upcoming trial, the task force investigates a series of mysterious deaths resulting from weaponized insects.

Liz and the Task Force investigate an infamous assassin who has a long history of weaponizing diseases, but has now turned to even more insidious activities. Meanwhile, Red and Dembe travel to Cuba in search of a lead, and Aram considers a new relationship. Elizabeth Bogush guest stars.

When Reddington takes Liz to the mysterious epicenter of his empire, their shared past reveals itself and long buried secrets are divulged.