Et kemisk angreb i undergrundssystemet får FBI til at sætte en jagt ind på den ansvarlige. Spændingerne mellem Elizabeth og Red tager til efter deres konflikt med Tom.

Liz er bortført af en mand som påstår at han er hendes far og Red forsøger at finde hende til ethvert pris.

In the two years following the death of Elizabeth Keen, Raymond Reddington and the members of the FBI Task Force have disbanded with Reddington's whereabouts unknown. When one of their own is injured in the line of duty, however, the Task Force is drawn back together to bring down a conspiracy that could shatter global security.

When a corrupt lawyer is linked to a string of corporate cover-ups, Red helps the team investigate her operation; Sen. Panabaker and Cooper await a judge's decision on the fate of the task force.