The officers bring down an auto-theft ring where young girls get rides with the victims, steal their cars, and take them to a "chop shop". Other calls include an elderly woman who ran a red light and whose license lists her in her 30s, a would-be motorcycle thief stopped by a feisty woman, a shut-in woman who thinks she is hallucinating while her nephew is hosting a marijuana party, and two men moving a safe down the street.

Malloy and Reed investigate a missing child with a Band-Aid on her leg. Other calls include rescuing a cat and birds from a woman who was trying to get rid of them using gas, apprehending a man who stole a disability check from his uncle, and responding to an auto burglary turned homicide with a Hispanic family more concerned with how the officers would treat them.

Officer Malloy pays tribute to Officer Tom Porter, who has recently fallen in the line of duty. Malloy recounts the close friendship they developed while training at the academy, as well as the moments where they crossed paths on duty, including the night of the officer's unfortunate demise.

Malloy and Reed search for a serial arsonist who spawns a copycat, settle a domestic dispute that results from a love triangle, rescue a man who wandered onto the ledge of a high rise and deal with a mentally ill man who is holding his wife at knife-point.

Malloy and Reed start the shift with a call to a liquor store robbery, where a fellow officer was shot but the owner of the store appears to be lying. Further investigation pushes the owner to admit one of the thieves was his brother and he was trying to protect him. In the meantime, they have a zoning issue with an elderly astrology reader followed by the report of a young boy asking a pharmacist questions about Seconal pills.

Officer Tony Johnson finds out he has been accused of a shakedown just after saving Malloy's life during a shootout. Reed and Malloy set out to find a bar girl named Ginger who Johnson says will prove his innocence, but her story leaves Malloy with an uneasy feeling.

Malloy and Reed are on patrol, and find a homeless man stabbed. They take a retired policeman, Jack Donohoe (who lives nearby), in for questioning, but he is released when the real suspect is found. Donohoe later gets involved in a shootout with a robbery suspect. Other incidents include an aspiring actress from Missouri shooting up a phone booth at Union Station after being lured by a theatrical agent who promised a movie career and took her money, and then having her suitcase, containing a rattlesnake, stolen at the station.

The officers respond to a shooting involving police and two black men, one of which was shot by one of the officers and later found dead in an alley. The dead man was the younger brother of Reed's friend Kenneth James; his older brother Cleotis was an accomplice and both were members of a black militant gang, The Brotherhood. Kenneth believes the gang's contention that Cleotis was murdered by the officers until the James brothers confront each other and Kenneth learns the truth; his brother Cleotis is arrested after briefly taking his brother hostage. Malloy and Reed also pull over an elderly driver on his 75th birthday for multiple traffic violations.

Malloy celebrates his birthday by having to let Reed drive 1-Adam-12 (due to Malloy allowing his driver's license to expire) and is nervous about his young partner driving the car. Calls include a bank robbery reported by the Bank robber, a burglary involving several neighbors, an abandoned baby, a suicidal wife who killed her husband on their 22nd wedding anniversary, and a drug dealer selling his wares out of an ice cream truck.

After beginning the search for a well known suspect who just stole a 600-pound offset printing press, Reed and Malloy try to convince an 85-year-old man to leave the soon-to-be demolished apartment building where he's resided alone for 27 years. Afterward, they pull over a very unusual vehicle, and chase a delivery truck to the end of an unfinished bridge.

Malloy and Reed are called to a riding stable run by retired actor Slim Berkeley. The owner is careless about trusting people and has $100 and a gold belt buckle stolen. Because of a criminal record in New York his young assistant runs, but when searched nothing is found. A call to a phone booth where the man inside is being attacked leads to a drug arrest and sore jaw for Reed. Reed spots a robbery at a drive-in resulting in a shoot-out.

Malloy and Reed investigate an extortion racket against a group of Jewish Holocaust survivors, with the owner of a dry cleaners willing to testify but others not out of fear of retribution. The officers return to handle the owner's panel truck being set ablaze and later the owner is physically assaulted. Malloy and Reed capture both suspects. Other incidents involved a robbery at a bar (the perps escaped initially, but are later captured after a shootout), and a drunk man owed back pay by a dockmaster threatens to dump his boat onto dry land from a crane unless he's paid.

Malloy and Reed are sent to assist the Los Angeles County Sheriff's Department with transporting a prisoner from Malibu to Los Angeles for outstanding traffic warrants. During the trip, the prisoner reveals he is also a witness in a mob murder and a hit has been ordered on him. Suddenly, the cruiser is ambushed on a rural road, a tire is shot out, and they crash on a dirt road out of radio range. Reed is captured by hitmen attempting to get assistance, but Malloy and the prisoner steal the hitmen's car to get to a phone. The LAPD sends a police helicopter to search for Reed, who ends up overpowering the hit men and are captured.

A phony prowler call results in shots being fired at Malloy and Reed. Shots ring out again when the officers head to the airport to transport a blood donor. The suspect is a known check bouncer, and Reed's wife gets a disturbing phone call. Later Reed heads home and meets an acquaintance who just happens to be driving the same car as the shooting suspect. Other cases include a suicidal man who tries to incinerate himself with gasoline, and a wino who is nearly shot by Reed.

Malloy and Reed deal with a woman who thinks she has a rattlesnake in her luggage, an out-of-town traffic violator, and a bar brawl, all while tackling armored truck robbers whose attacks have been predicted in advance by an informant.

Malloy and Reed investigate the ransacking of a college football locker room and uncover a controversial performance enhancing drug program. They also investigate suspicious parents who backtrack after their maid reports their baby as missing, apprehend a reported prowler who is then suspiciously let into the home by the female accuser and engage in a bullet-riddled high speed chase through a residential area.

On temporary assignment at LAX, Reed and Malloy have to save a stewardess who is taken hostage inside a lounge by a man desperately trying to get the attention of a television producer. Afterward, they go undercover as rental car employees to intercept a large narcotics delivery from Toledo, and then try to identify and apprehend a rape suspect before he's able to escape on a flight.

Malloy and Reed search for a six-year-old boy who was apparently abducted while walking home from school, and later fear that an elderly witness's wildly inaccurate account may actually pertain to a different crime. They also respond to a barking dog complaint and become suspicious of the dog's owner, mediate a domestic dispute caused by a husband's obsession with watching football, respond to a very creative college prank and pursue armed robbery suspects through a crowded train depot with the aid of a police helicopter.

Malloy and Reed back up Officers Wells and Brady (who, like Wells, likes to "do things his own way") on a domestic dispute involving a husband with a gun. Calls include a dead body which turned out to be a girl playing with a mannequin, a man who likes to climb the sides of abandoned buildings, and a taxi driver who tips off the officers to an in-progress pawn shop burglary; they find the suspect working at a car wash and arrest him. The officers once again back up Wells and Brady on a prowler call where the homeowner comes out shooting. The four officers also hone their skills on the firing range in preparation for their monthly qualification.