Zack and Cody have two pet rats as a science project. Mr. Moseby gives the twins tickets to a Red Sox's game to get them away from the hotel. Then a hotel inspector seizes control of the Tipton, because of Zack's mistake. London has a dog party for Ivana and Maddie has to plan.

Carey gets a secret admirer. Zack and Cody end up hooking her up with the wrong guy. Now they have to find the right guy that is Carey's secret admirer. Mr. Moseby and London get ready for Mr. Tipton's arrival.

There is a Battle of the Bands competition being held at the Tipton Hotel. Zack and Cody, along with Max and Tapeworm compete against Maddie's band in which has London in the band.

Cody ends up going away to camp. Zack starts to miss him, and has to find a way to get to him. London ends up learning how to drive, with the aid of Mr. Moseby.

There are a couple of jewel thieves in the Tipton Hotel. Zack and Cody have to try and find out who it is to clear up someones name.

When the twins find out about hidden treasure in the Tipton, everyone goes into a frenzy looking for the money.

London's father goes broke due to an investment in a diamond mine. London now has to move in with Maddie. Zack and Cody wonder if their parents ever got them mixed up when they were babies.

London develops a crush with the son of a rival hotel owner, of which Ilsa is the the manager. Zack and Cody bake cookies to be served at a ball held at the Tipton.

London spreads a rumor she started about Maddie, and Maddie accidentally spreads one about London. Cody wants to look different, because people kept on thinking he was Zack. Cody has Zack fill in for him on an interview, because of a certain problem.

Carey needed some help, so Mr. Moseby ends up taking Zack and Cody to a baseball game. Mr. Moseby get into some trouble due to an incident at the game. London sets Maddie up on a blind date, in which Maddie ends up having a really bad hair day.

When the twins find out about a ghost in Suite 613, Zack will stop at nothing to meet the ghost. With some help from Maddie and London, the twins come face to face with the ghost of Irene.

Cody is inspired by a guest speaker and tries to do the same with his friends - to hilarious results. Meanwhile London and Maddie compete savagely in the fashion shootout of the year to get on the cover of Teen Trends.

The news of a visit from Mr. Tipton gets the employees excited (and reminiscing) about their good deeds as to who deserves a possible bonus… but when they find out Mr. Tipton is in a bad mood and will fire someone, all fingers point to Carey because of the boys' mishaps, but Zack & Cody come up with a plan. In the end Mr. Tipton fires Muriel not knowing she retired 2 years ago.