One of the escapees from the Phantom Zone has killed the crew of a ship in Seattle. Clark confronts the killer who feeds on the bones of his victim. In Smallville, a patient in LuthorCorp Labs escapes experimentation and seeks revenge on Lex by trapping him in a dimension where he can see and hear those around him, but they cannot see him.

Clark and Lois meet Smallville's newest arrival face-to-face, and she has some surprising news. Clark decides to leave Smallville and continue with his superhero training but Jor-el informs him that a new Kryptonian menace has arisen.

Kara goes to Washington to look for her missing crystal, but is captured after she breaks into the lab. She's sedated with a truth serum that has kryptonite in it, which makes her relive a trip to Earth from the past. In this past trip she followed Lara, Clark's biological mother, to the Kent's farm. Clark saves Kara, but also ends up being affected by the serum when he burns it with his heat vision.

Tess and her team perform tests on the crystal she retrieved from the Arctic, causing it to send a beam of light into the universe; the beam of light triggers the arrival of Maxima, a queen from another planet looking for her soul mate.