After discovering that Chloe's body isn't in her coffin, Clark and Lois Lane investigate but are stopped by Lois' father, General Sam Lane. They believe General Lane knows more then he's telling, and figure out he's been in contact with Lex. Meanwhile, after Lana's sudden departure Jason follows her to Smallville. And Lionel sends a mutant killer to determine if Chloe is alive and kill her for sure.

Abigail, an ugly high school girl, gets plastic surgery from her surgeon-mother to boost her popularity. However, her beauty hides a dark secret - when she kisses someone they're inflicted with life-threatening hallucinations. When Lana sees Abigail with one of her victims, she becomes the next target.

The General and Lucy Lane decide to drop in on Lois and Clark for a surprise Thanksgiving dinner. Clark and the General get off to a rocky start after Lois’ father bashes the superheroes and tells Clark he is trying to pass a vigilante registration law. Meanwhile, in an effort to stop the vigilante registration act from being passed, Rick Flagg lies to Lucy in order to lure Clark away from the farm long enough for him to assassinate the General. Lois is torn between making her father proud and her love for Clark.