Clark visits Metropolis in this episode, and does a secret good deed - a police detective witnesses this and decides to look into it. He contacts Lex and reminds Lex that he knows about his past in order to get him to talk. The detective, Phelan, discovers that Clark had been around many "accident scenes" in recent months, and he decides to look into it. Phelan begins blackmailing Clark to help protect him from an IA investigation. When Clark balks Phelan frames Jonathan. Clark manages to set up Phelan for the theft of a rare piece at a museum and Phelan is killed in the shootout before he can tell anyone about Clark's secret. Lex is left to wonder at the superspeed image captured on a museum camera.

Abigail, an ugly high school girl, gets plastic surgery from her surgeon-mother to boost her popularity. However, her beauty hides a dark secret - when she kisses someone they're inflicted with life-threatening hallucinations. When Lana sees Abigail with one of her victims, she becomes the next target.

Clark decides to join the football team over Jonathan's wishes and gets the starting quarterback position when his predecessor attacks Jason over a girl. Clark and Lois investigate and discover that the cheerleaders are using kryptontie in the team's water supply to turn them into obedient mindless boyfriends.

A Luthorcorp experiment is released into the atmosphere - a toxin that causes its victims to hallucinate their worst fear. Chloe, Clark, Lana, and Jason all fall fictim to the toxin, and Lex, desperate to find a cure, takes a dangerous antidote. Meanwhile, Lionel is released from prison and his conviction overturned thanks to a mysterious benefactor.