Having been transported to the Fortress of Solitude, Clark is confronted by Jor-El, who tells him he cannot return to Smallville, instead he must stay and prepare to save the planet. Also, transported to the Fortress, Chloe is unable to handle the sub-zero temperature and collapses, begging Clark to use his powers to save her. Jor-El forbids him to leave, but finally acquiesces, telling Clark he must return before sunset or there will be dire consequences. Meanwhile, Lana is horrified when she sees two Kryptonian aliens emerge from a spaceship discovered in the remnants of the meteor shower. The two aliens destroy what's left of the town searching for Kal-El.

At a party at Crater Lake, Lois is saved from drowning by Arthur "A.C." Curry. Arthur has incredible swimming abilities, but also a secret agenda aimed at...Lex. Meanwhile, Professor Fine discussed Lex's weapons-manfucturing operations with Clark.

Lana joins a sorority to get housing for her last-minute college registration, but the sisters have a deadly agenda which involves turning Lana into a vampire like themselves and sending her against Clark. Meanwhile, Chloe applies to become an intern at the Daily Planet and runs up against the editor-in-chief, Pauline Kahn.

Clark gives into paranoid delusions brought on by exposure to new "silver" kryptonite, and Professor Fine is the only one who can save him... before he kills Lana.

When Martha comes down with a strange disease, Professor Fine convinces Clark that Jor-El is responsible and that the Fortress must be trying to eliminate the father of Kal-El. But Professor Fine has an ulterior motive which comes to fruition when they arrive.

Clark is hypnotized by a woman who uses a supposedly magical charm to control others - he reveals his super powers and is sent to kill Lex. Meanwhile, Lex has tracked down the missing Professor Fine and plans to confront him, unaware that Clark is coming to murder him.

Clark and Martha are both visited by Jonathan's ghost, who warns them about Lionel and claims that Clark must kill him to stop him. Meanwhile Fine will do whatever it takes to get the vaccine from Lex.

Professor Fine has unleashed a virus that will kill millions. Clark must put a stop to him, while Lex wonders what happens when he will tell Lana his newest secret.

Chloe begins to notice that Clark's not acting like himself. Bizarro enlists the help of Brainiac.

Clark must learn a new superpower as he and Kara join forces to take on Brainiac, putting the lives of their friends in danger.

When Clark wonders if the world would be better off if he never came to Smallville, Jor-El shows him what life would have been like if he had never existed.

Lex is taken to the Fortress to fulfill his destiny, while Lana awakens from her coma and Chloe is arrested by the government.

In an attempt to cheer up Clark, Lois convinces him to attend their five-year high school reunion. A visit back to the home of the Crows has Clark remembering old times with Lana and Chloe, while Lois is furious that no one remembers her five days as a student. Brainiac 5.0 uses his Legion ring to visit from the future and takes Clark through his past, present and future. He shows Clark what really happened the night Jonathan died, Oliver’s current pain and Clark’s future at the Daily Planet with Lois and his role as Earth’s favorite red and blue superhero.