Lana reads a spell book belonging to her 17th century ancestor, the witch Isabelle, and becomes possessed by her spirit. Isabelle resurrects her other two witches and together they seek out the kryptonian crystals, using their magic to render Clark powerless.
Lex is accused of killing a young woman and Clark turns to Lionel for help. Meanwhile, Lana has a dream of her ancestor and a mysterious second woman - a dead ringer for Jason's mother Genevieve, who arrives to visit her son and his new girlfriend.