After the body of Lois Romney is found in a hotel room, Goren and Eames link her to Dale Van Acker, a junkie and the son of wealthy scion Priscilla Van Acker. Van Acker strongly disapproved of her son's pregnant fiancée, which leads Goren and Eames to suspect she may have wanted to get rid of the girl on a permanent basis.

When a European con man is found beaten to death, the detectives look for the investors he swindled, learning quickly that the man also had relations with their wives.

The detectives investigate a murderer who poisons hospital victims with cyanide. They suspect a nurse whose profile is typical, but when they discover more murders away from the hospital they have to widen their search.