Tracking a modern-day Bonnie and Clyde, Goren deduces that one of his suspects has an injured foot. It isn't long before Goren and Bishop realise that the pair, who have already killed nine people including two undercover cops, are not the typical Bonnie and Clyde -- the female partner is obviously the one in control.

Goren and Eames stumble upon a web of corporate corruption involving fraud, bribery, identity theft, and a conspiracy to sell lethally-contaminated blood products as they investigate the murder of a pharmaceutical salesman.

After he gets into the head of an insane man driven to torture, murder, and cannibalism by overwhelming despair and loneliness, Goren surprises his colleagues with a passionate plea that the man be spared the death penalty, and engineers the confession that will save the man's life through a plea bargain.

When Goren and Eames investigate the death of the new owner of a "little black book" once belonging to legendary playboy George Merritt, they uncover the marital indiscretions of a U.S. Senatorial candidate involving sex clubs.