Sam's ex-husband shows up and wants to take Alex on a trip. Gallant is back and Neela hopes to see him before he goes back to Iraq.

Pratt and Weaver try to create a Christmas miracle when they work to save a girl wounded from gunfire. Eve gets into trouble after punching a disruptive patient. Also, Abby has a special gift for Luka.

Pratt departs for Africa with attitude to spare but makes his first contact with harsh reality before the plane lands. Abby senses something is not what is seems when she treats a 12-year-old and her grandmother, then differs with Luka over the best course of action. A prisoner is brought to the ER with what everyone thinks is a fake case of appendicitis. Morris is dressed, and ready, to impress, but Albright’s not. It’s time for Kerry to return to work and Clemente doesn’t know when it’s time to leave.

Chaos reigns in the ER when two prisoners are brought in for treatment, but instead plot a violent escape. Their desperate actions place one doctor in harm's way, and forces one nurse to become a tool in their plan.

Weaver, Kovac, and the other doctors work frantically to try to save Jerry and a pregnant Abby, who were both critically injured during the shootout that left the ER in shambles. Meanwhile, Sam tries to escape from her ex-boyfriend and his criminal accomplices as they head north, but things quickly turn violent.