A day's worth of trauma takes its toll on the men and women of the ER. Dr. Greene looks into leaving the ER and joining private practice. Among other events, multiple casualties are brought in when a building collapses. New medical students report for duty, including Dr. Benton's new trainee, the young and inexperienced John Carter.

Carter trains one of Benton's new students, Deb Chen. Hathaway has her hands full with an emotionally challenged patient who's obsessed with colors. A sociologist provokes people to measure their reaction times for a study. Kayson brings charges against Susan in the Vennerbeck death, leading Morganstern to question Susan's assertiveness. Benton and Walt hunt for Peter's missing mother.

Doug's one-night-stand has a seizure and he brings her to the ER.

Carter plays tour guide for Ruth Johnson, who was born in the hospital 100 years ago to the day, and her large family. Carol treats a boy who was hit by a car and tells a story of being chased, his friend being shot in the process. Peter observes Kotlowitz install a cochlear implant and decides to wait before scheduling an operation for Reese. Mark dines with Dr. Lee, new ER chief. Dr. Corday proposes radical changes in scheduling at an M&M conference, and later decides to break off her relationship with Benton.

As Carter prepares to open a new facility for the underprivileged, some old friends/colleagues gather. Rachel Greene, Mark Greene's daughter, applies for an internship at County.