Abby and Neela are assigned to a month-long rotation in the neonatal intensive care unit where they experience emotional roller coasters while caring for the sick infants.

As Abby and Luka cope with their newborn's life and death struggle, the couple is shocked to receive a surprise visitor: Abby's mother Maggie. Meanwhile, Sam fears the prospect of criminal charges; Neela discovers that Tony Gates will be joining the ER team as an intern and Morris gets his job back while Weaver gets demoted.