An obnoxious talk show host known as ""The Peoples' Voice"" begins to receive death threats, and the Chief is assigned to protect him. Firstly he must overcome his own feelings of dislike for the man, but are those feelings entirely misplaced? Events escalate when the host's wife is killed by a car bomb apparently meant for her husband.

Barbara Jones, the amnesiac victim with whom the Chief once fell in love (season one episode Barbara Who), calls Ironside in when her daughter is kidnapped. Not only is it a difficult case, but the Chief has an over eager Sheriff, a jealous husband and his own feelings to contend with, as he attempts to find the girl before it is too late.

A judge decides to begin a series of lectures about a case that he tried eight years previously, the result of which was that a man was executed. Immediately he starts to receive death threats; but with no clues to help, the Chief may not be able to find the would-be murderer - who may, it appears, have committed the murder in the original case as well.

A string of murders is committed, and in each case the victim has a numbered disk in their possession. After number four is found dead, it transpires that the Commissioner is the owner of disk number six; and the Chief disguises himself as number five - an irascible artist to whom he bears a striking resemblance - in order to keep him alive.

When her fiancé is accused of murder, a young woman comes to Ironside for help; but when it transpires that the fiancé in question is an old Naval acquaintance of the Chief's, a man with whom he did not get along, the assistance is both offered and accepted somewhat grudgingly. It soon becomes clear, however, that the prejudice which exists in the couple's home town is in serious danger of destroying an innocent man's life.

Ed gets grounded in Reno whilst transporting a murder suspect back to San Francisco, and knowing gunmen to be on his tail he hides out in an abandoned bar to await assistance from the Chief. As he soon discovers, however, there are other dangers besides hit men for him to worry about, before he can meet up with his colleagues and deliver his prisoner to jail.