When a reverend fighting against drug deals in Donovan's old neighborhood gets killed, Donovan's sister is killed as well. Donovan investigates and is arrested for killing one of the men responsible, and Frank engineers a Backstep to go back and save his friend.

Parker teams with an old friend, a Navy SEAL, to prevent the assassination of the new president of Columbia at a White House state dinner.

Mentnor's post-World War II experiments return to haunt him, as a virus that causes homicidal madness gets loose in an isolated New England village.

While on a mission to prevent the murder of the U.S. Attorney General by a religious zealot, Parker is plagued by flashbacks to a disastrous mission in Somalia where the rest of his team were killed.