After yet another Homer and Marge fight, Homer ends up sharing a condo with two homosexuals - who don't exactly think Homer is straight.

Vi følger Homer og den resterende familie Simpson i dagligdagens hændelser i Springfield.

When Smithers transforms Moe's pub into a refined and trendy lounge, the establishment becomes Springfield's local gay hangout; Principal Skinner falls for the new, free-spirited music teacher (Kristen Wiig).

Marge leder efter arbejde og begynder at sælge plastikbokse til opbevaring af mad. Imens prøver Lisa at gøre verden til et bedre sted ved at blive drag-queen.