The Camdens, especially Lucy and Ruthie, grow concerned that an unusually joyful Annie isn't dealing with her true emotions following the death of her father Charles, but the happiness proves to be infectious as it soon spreads through the family and all over town. Meanwhile, Eric tries to convince an unhappy Chandler that he should consider adoption. At the same time Chandler is approached by a mysterious young girl who gives him a cryptic message before she disappears.

Prospective homeowners Lucy and Kevin are ready for a fight to the finish when they learn that Chandler and his soon-to-be-adopted son Jeffrey are their rivals in a bidding war on a house. However, the conflict sparks an idea with Eric and Annie who decide to use their savings to buy their house from the church. Meanwhile, Ruthie is upset with Martin because she thinks he will get the garage apartment instead of her when Lucy and Kevin move out, and Peter suspects that his dad might be having an affair.

Lucy and Kevin celebrate their one-year wedding anniversary and contemplate whether they're ready to start a family, but things don't go off smoothly as Lucy refuses to drink champagne with Kevin during their anniversary dinner. Cecilia and Martin realize that their relationship may face a rocky future if Cecilia goes away to college. Chandler's foster son asks him to rid their house of all alcoholic beverages.

Peter lies to Ruthie about his plans for the evening when she asks him to help her baby-sit the twins. With that, Peter goes missing, but concern turns to disappointment when Eric and Vic find him drinking alcohol with his friends at the park.

Lucy finds her husband Kevin and his partner Roxanne in a compromising position while on an undercover police assignment, Cecilia and Martin's relationship hits another bump in the road when their after-school commitments get in the way of one-on-one time, and Chandler may have bitten off more than he can chew as a new parent. Ruthie and Peter get stranded after missing their bus during a school field trip. However, fate intervenes when the youngsters cross paths with Lost Boys Nicodemus and Jacob, who not only take care of them until Reverend Camden arrives, but also share the heartbreaking story of their struggle to stay alive.

It's Camden chaos all around when Matt, who is having problems in his marriage to Sarah, returns to Glenoak for a visit and runs into his ex-girlfriend Heather on his flight to Glenoak. Simon unexpectedly announces he's coming home for the summer.

Also, Lucy sets out to discover why Roxanne is suddenly too busy to hang out with her as she's convinced that Roxanne is secretly trying to become a detective behind Kevin's back. Ruthie keeps a secret about a fellow student from her parents. Lastly, Martin learns that his baseball teammates think he's having sex with Cecilia.

The Camden chaos continues with Matt, who is trying to salvage his marriage, questioning whether he still has feelings for his ex-girlfriend Heather; Simon's return to Glenoak creates conflicted feelings for his ex-girlfriend Cecilia, who is torn between her feelings for Simon and her current boyfriend Martin; Ruthie's foreign exchange student friend Maria, appears to be making the moves on Ruthie's boyfriend Peter; and grandparents-to-be Eric and Annie hop a plane for New York, despite Mary's repeated pleas for her family to stay away.