When a command pilot learns she has a brain disorder she must learn to cope with not being able to fly a plane anymore. Dr. Stowe tells Jane that it would be wise to quit her job as an airline pilot before her disease progresses to where she will be unable to do her job properly.

Dana questions whether or not to put her patient's privacy at risk as well as her own career as a doctor by telling the airline that she can't do her job anymore due to her illness.

Dana cares for a dying patient who has been disguising herself as a man in order to fulfill her calling to the priesthood. Lu prescribes Demerol for a woman suffering from sickle cell anemia, but the woman's local pharmacy will not carry high-priced drugs for fear of robbery.

Dr. Campbell's diagnosis of the first local case of West Nile Virus causes a near panic in the community; Lu tries to help a hard-working mother remain close to her hospital-bound son.

When a patient of Andy's takes a turn for the worse under Lu's watchful eye, the two doctors butt heads over whether proper procedure was followed. Meanwhile, Andy questions whether or not she can trust her oldest daughter. Also, when Andy and Morton try an experimental xenotransplant (using the heart of a chimpanzee), Peter questions the rights of the animal.

An Indian heiress with a deformity turns to Andy for treatment so that her parents can arrange a marriage for her. Things get complicated when the woman realizes that she will lose the freedoms she has been afforded because of her imperfection. Also, Lu helps an older woman with Alzheimer's use her past for her own benefit. Meanwhile, Andy counsels a young woman who is seeking ""revirginization"" surgery.

An estranged sister must work up the courage to ask her Olympic gymnast sibling to donate her liver to save her life. Andy and Kayla help a clinically depressed and struggling resident get back on track after a suicide attempt. Lu tries to convince Jonas not to build a large discount multi-purpose store in her neighborhood as it would close down many of the mom and pop stores that had been there for years.