Dr. Lu Delgado is running out of money to run her free clinic by herself. When Lu goes to prestigious Rittenhouse Hospital to ask for assistance, famous O.B.G.Y.N./surgeon Dr. Dana Stowe blames Lu for ruining her breast cancer study to find a cure for cancer after Lu tells a woman her opinon about test studies. Dana later is asked by Chief of Staff Dr. Bob Jackson to tour Lu's clinic and see if the clinic should get funded by Rittenhouse . Dana tells one of her patients that she has ovarian cancer and that she will not be able to have any children even though she has the desire to. In the end, Dr. Lydia Emerson comes up with the perfect solution to Lu's problem.

In a special episode of Strong Medicine, the Rittenhouse Hospital Emergency Medical Services team is introduced. EMTs Kate and Zach are attacked while trying to save a young girl's life, figure out the motive behind it, and reach a dubious resolution. Then, a multiple vehicle accident keeps them and Dr. Vanessa Burke, an African American trauma surgeon and Katie's adoptive sister, busy. A chemical spill threatens the lives of those in the accident and a guilty driver makes an impulsive decision. Meanwhile, a pre-teen in the accident needs a transplant and Katie and Lu search homeless shelters for a match. Even after they find one, they still face some difficulties. Vanessa amputates the legs of a man who begged her to let him die and must convince him that life without legs is still worth living.