Dana treats an HIV positive patient of Lu's when Lu is out of the clinic and learns that his mother took him off the HIV medication with Lu's permission. She is furious and reports the mother. Although the boy suffers terrible side effects from the medication, Dr. Bob Jackson insists that he be put back on it. Dana falls for her handsome intern.

Dana's former beauty queen patient doesn't think her husband finds her attractive and insists on having extensive plastic surgery. Dana refuses to perform the surgery but when Terri Ann lands in the ER, she begins to doubt her decision. Peter tries to figure out why a transvestal is having side effects of menopause and counsels Marc about one of the stickier issues of adolescence. Lu and Lana try to find an appropriate punishment for two young teenagers who spray graffiti outside the hospital.

Lu coaches a teenage basketball team and is troubled when a player faints at a game. She later finds traces of steroids in her blood and wonders if the entire team is on the drugs. Dana is mystified when a complete stranger shows up in the ER with Dana's name and phone number in her purse. Dana must make a difficult decision for the women and regrets that she can't find her family so they can decide.

Dana has big problem on her hands when Susan Jackson comes to the hospital with bruises. Dana wonders if Robert Jackson gave her the bruises because their marriage problems. Dana gets the feeling Susan may not be telling her all she knows.

After Dana learns Robert found his wife at the bottom of the stairs Susan tells that had double vision leading Dana to believe Susan might have Multiple Sclerosis.

It's Breast Cancer Awareness Weekend at the Rittenhouse Hospital Women's Clinic, where Lu (Rosa Blasi), Lana (Jenifer Lewis) and Peter (Josh Coxx) are hosting a dance-a-thon and a free mammogram clinic. When one woman's mammogram reveals a lump, she must choose between losing both her breasts and losing her job. After Dana (Janine Turner) delivers the unexpected results of her breast cancer clinical trial, she learns the very disease that's defined her career has now hit too close to home.

A woman's advanced Parkinson's disease forces Dana and Robert to decide whether to perform a controversial fetal cell transplant. Peter's stint as a nude model leads to a romantic interlude with an aspiring painter whose muse puts her in the emergency room. When Lu treats one of her son Marc's classmates for a broken wrist, she discovers that alcohol has hit junior high.

It's Christmas at Rittenhouse Hospital. A woman engaged to be married finds out she's pregnant — even though she's a virgin. Robert fires a kitchen employee, assuming her to be drunk on the job. Lu later diagnoses her with Lou Gehrig's disease. Lu's son Marc develops a crush on a runaway teen.

A journalist comes in with an infection on her foot and Dana(Janine Turner)realizes that she is actually a closet heroine addict. Lu (Rosa Blasi) is called to the emergency room when her patients, a deaf family, are brought in following a fire in their apartment building. She worries about their safety and suggests a risky ear surgery for them — but the husband disapproves. Lu brings her boyfriend home to meet Marc(Chris Marquette).

When a 12-year-old girl is diagnosed with oral gonorrhea, she tells Lu (Rosa Blasi) that she got it from her teacher. Lana (Jenifer Lewis) takes on a new role at Rittenhouse: that of patient. Two of Dana's patients deliver babies — and both newborns have the same father.

It's an all-nighter for Lu at Rittenhouse — and there's not a moment's rest. Robert's wife, Susan, is back in the hospital as her MS progresses. A baby is kidnapped — from a pregnant mother's womb. And Lana's blind date ends in the ER.

Lu travels to Puerto Rico, where her beloved grandmother urgently needs a bone-marrow transplant to survive. As the headstrong doctor copes with this life-or-death situation, she flashes back to her days as a resident, recalling her first meeting with Peter and Lana. Mary J. Blige guest stars as a moody blues singer named Simone.

A woman hoping to form a maternal bond with her adopted teenage daughter ignores Dana's advice and proceeds with plans to re-create the child's birth. A second patient of Dana's seeks Lu's care after falling on hard times. Outside the hospital, Marc is caught cheating at school.

Dana debates whether she should risk her relationship with Nick to comfort a terminally ill flame from her past, while Lu faces off against a Philly police officer who mistook a diabetic for a drunk driver.

Dana waits for Nick to decide when they will get married, and treats a figure skater who's determined to compete in the Olympics despite being diagnosed with osteoporosis. Elsewhere, Lu takes an instant dislike to her son's new girlfriend's father (Don Michael Paul). Lana looks forward to graduating from high school. Peter finds his new romantic relationship to be fleeting.

Lu's return to her college alma mater is marred by an outbreak of meningitis. At the clinic, Dana develops symptoms suggesting she is pregnant.

Dana is troubled when a patient requests new breast implants immediately after her first ones rupture. Elsewhere, Lu fears for the life of a wanted criminal's sickly newborn.

Lu is raped by Rittenhouse's star surgeon — but he insists that the sex was consensual. Meanwhile, Dana attempts to help a critically injured woman whose car crash may or may not have been an accident.

Lu copes with the trauma of being raped by devoting her thoughts to a patient who accidentally overdosed on over-the-counter cough medicine. Dana, meanwhile, grudgingly turns to Dr. Kilner for advice about a pregnant woman with colon cancer.

Lu tries to cope with the aftershocks of her rape, she finds her life spinning out of control. Her rage causes Robert to dismiss her from Rittenhouse, and at home her son Marc barely recognizes her. Meanwhile, one of Dana's patients agonizes over whether to continue with in vitro fertilization, which will likely hasten the progress of her deadly disease, LAM.

As Dana's upcoming birthday makes her decide to seek a volunteer sperm donor so that she can have a child, she is confronted with a newborn who is HIV-positive. Lu is accused by an enraged mother of being responsible for her teenage daughter's sexually-transmitted disease because Lu provided the girl with birth control.

A teenage cancer patient refuses to continue chemotherapy, Dana makes preparations for what she assumes will be her forthcoming pregnancy, and Lu finds herself in the middle when she suspects abuse in a family.

Andy goes beyond the call of duty to expedite the Food and Drug Administration's approval of a drug that could help Robert's wife, who has multiple sclerosis. Also, Andy intervenes when a family is accused of endangering the life of their young daughter. Meanwhile, a woman with terminal lung cancer claims to be Lu's half-sister.

Andy is forced to confront her father after discovering that he has a degenerative nerve condition that could threaten his independence; Lu treats a pregnant woman whom she subsequently discovers is under investigation in connection with several unexplained infant deaths.

Andy helps Jesse cope having back surgery and trying to set things right between her husband. Lu tries to figure out how to spend time with Mickey and Marc. Lu wonders if Mickey would like to live with her.

Andy is worried about whether she should help in her daughter's surgery. Dr. Jackson deals with death of a young girl 6 years ago.

In a surprise twist following the suspenseful season finale cliffhanger, Mickey jumped in front of Lu and took the bullet for her; saving her life. Lu quickly rushes him to the hospital but little can be done to save his life besides putting him on a respiratory machine. Andy and Bob try to convince Lu to take him off the respirator. While Lu deals with the emotional trauma of Mickey's death, Andy tries to perform an experimental procedure on a baby in a bubble but is interrupted by Bob with news that the FDA has un-approved the procedure. Meanwhile Andy gets herself into a bureaucritical battle when she tries to get a patient who has no health insurance a free heart transplant. Also, Andy must tell Lizzy and Jesse that she and Les are getting a divorce and that he is moving across the country.

Andy and Milo treat a woman with an enlarged heart and conflict about what surgery to perform on her. Lu gets angry with Marc after he stays out until after midnight and insists that she babysit him until he is more responsible. Andy tells a sexually active elderly woman that she has HIV. Lu finds out about a terrible hospital error when trying to find a matching bone marrow for a young leukemia patient. Lana and Peter search the inner city for a woman whose aorta could burst at any time and face some frustrating difficulties.

When Andy encounters a young woman with amnesia and her fiance, she must decide which secrets should remain untold. Meanwhile, when a pregnant patient refuses to stop using drugs, Lu faces an ethical dilemma and must decide whether to intervene.

A friend of Marc's may be being abused by her boyfriend. Lu treats an HIV-infected woman who looks sicker than she is. An obese couple persues gastric bypass surgery. Dr. Jackson sends Nurse Riggs on an unusual assignment that may turn into another career.

Andy worries about a patient who continues to ask for surgery to make her breasts perfect even after she has had many surgeries. Andy warns her patient that if she continues to have more surgery she could make it harder for machines to detect a possible sign for breast cancer due to the fact that she has a lot of scar tissue. Andy believes her patient may have a body-image disorder and is worried that her patient could go to extreme measures to improve her body image. Lana's computer breaks down with Marc's thesis on it and Lana, Peter, Ben, Lu, and him must pull an all-nighter to get it done and get the thesis done and turned in in time. Lu must say good-bye when Ben is transferred to Miami and Marc goes away to college.

Lana bets her pink feather pen that she'll sign up more people than a friend will for the Rittenhouse Breast Cancer Walk. She faces some difficulties, however, and goes to extreme measures to get people to sign up. Lu tells a teenaged patient that she is pregnant and she in turn tells Lu that Lu's son Marc is the father. In a shocking ending, the girl reveals a horrifying secret. Andy, meanwhile, takes action when Lizzy's friends receive ""fat letters"" and instead makes the school food healthier when Lizzy starts to severely diet.

TBA