Jess goes to Quantico to train to be an FBI agent after Brooke transfers to San Francisco. Jess is passed from the training school by powerful John Pollock to work with her new partner, rule-breaking hip Nicole Scott as well as evidence expert Antonio Cortez. In the team's first case, a teenaged girl is caught on a survelliance camera stepping on an elevator with a stranger at a shopping mall. The elevator goes down a floor and opens to reveal an empty car. The girl is not seen for days after this incident. Nicole and Jess must work together to use Jess' visions and Nicole's experience and street smarts to solve this case.

A woman fearing for her life makes a panicked 911 call. The next day blood is found in the hotel room she shared with a fraternity boy on a one night stand. Nicole and Jess expect that they are searching for a body but find out that they have been misled. Nicole and Jess could be in danger from a serial killer on the loose.

A woman sees her son, whom she believed died ten years earlier in a car accident along with his father, on television at a football game. The boy's father's body was found and the boy was assumed to be dead in the horrific car accident. Nicole and Jess must find both the boy and his father's murderer. Also, Nicole believes Jess' dreams are about her and doesn't feel flattered.

A public bus that was traveling from Boston to Atlantic City, New Jersey is found in rural New Jersey with the twenty passengers (including an 8-month pregnant woman) and the driver mysteriously absent. Nicole and Jess find out that a man traveling from Boston to Miami on a bus from the same company that left at the same time was beat up and had his luggage stolen. Jess has no idea what her dreams involving a man eating garbage and screaming coming from behind a red door mean. Jess and Antonio discourage Nicole from re-starting her smoking habit which she gave up five years earlier.

A woman is found murdered in New York City's Central Park but before police arrive at the scene the medical examiner, the hearse, and the driver disappear along with the body. Eventually the body along with the boides of the medical examiner and the driver are found cut open. Assistant Director Pollock identifies the body as that of an unprofessional undercover woman he had been using to get information about a gang of bank robbers. Jess has dreams about the snitch getting the electric chair and of Pollock kissing the woman.

A rebellious teenager has an argument with her parents, storms out of their suburban home and drives away. When she returns hours later her parents and younger brother have disappeared. The teenager and her boyfriend are the top suspects until a body is found that breaks the case wide open. Also, an infamous red light camera sheds some new light on the case (and on their feasibility). Nicole and Jess have to deal with a rude Drug Agency officer who won't let them investigate a murder Jess dreams about because of its drug relations.

An empty police car is found with blood on the dashboard and two police officers have gone missing. Jess and Nicole quickly discover a police department full of corruption. After Jess witnesses a shocking murder, she must find out which of the many suspect or suspects is a cop killer. The police chief suspects an old enemy of his who shows up in Jess' dream about the police officers having a party. Also, Nicole must negotiate with a crazed man holding three people hostage.

A senator's senior aide's five year old daughter is kidnapped. The unlikely kidnapper leads Jess & Nicole to a missing reporter who was working on an article about Chinese people being smuggled into the United States. The team discovers that the reporter may have gone a bit too far undercover. Jess dreams about a dead man pointing at something. Nicole & Antonio put their jobs on the line to solve this case when John forbids them to work on the case any longer.

After a horrific car accident, a famous pop star's bodyguard is seriously injured. Meanwhile, the singer, who was in the car, has vanished. The investigation leads them to an obsessed fan who has been sending the singer letters that could be perceived as threats. Nicole & Jess also stumble onto a sad story of a reluctant adoption during the search and another person goes missing. Jess dreams about a psychic with tarot cards.

Jess, Nicole, and Antonio search for a missing woman who was delivering subpoenas. They soon discover that one of her deliverees has also disappeared. The case exposes a world of loneliness, corruption, and identity theft. Also, Jess worries that her job is dwindling her social life.

The team searches for a missing veterinarian and a missing working woman from the same Maine town. The veterinarian disappeared from a dock behind his house when his wife stepped away for a few minutes and the woman was reported missing from work. Meanwhile, Nicole is amazed when she learns than Antonio was married and divorced. Also, Jess dreams about blood. Later, the shocking discovery of a body turns the case upside down and a former F.B.I. agent joins the team in the thrilling first part of "Truth or Dare".

Jared Hart and some assassins attempt to eliminate another member of the witness protection system. Nicole and Jess follow in their footsteps while Antonio and John try to figure out how Hart is locating the innocent victims. Meanwhile, the search continues for Jared's wife and one or more members of the team may not survive the shocking case in the breathtaking conclusion of "Truth or Dare".

Nicole goes undercover when a criminal she formerly went undercover with kidnaps an innocent woman because she is related to one of the agents who put him in jail. She learns of a deadly plan of revenge for his years in jail. Also, she must somehow avoid his sexual advances without blowing her cover. Meanwhile, Jess deals with the stress of being Nicole's outside contact and has a vision in which the kidnapped woman shoots and kills random people.

After arresting a dangerous man on the run, Jess and Nicole find a man shot in the head hanging on to life in the trunk of the car he was trying to steal. The man has amnesia and doesn't remember anything. The bullet leads the team to believe that he's connected in some way to the disappearance of a young heiress and they must decide if "John Doe" is innocent or guilty while trying to figure out his identity and the circumstances of his near-death.

Antonio's ex-wife's sister is kidnapped. The team wonders if she was taken by a bitter victim of his ex-wife, who is a successful District Attorney or if it was done randomnly. A later attack blows the case wide open. Jess dreams about a little girl and toys. Meanwhile, Antonio and his ex-wife must deal with the emotions that are opened up between them.

A married woman goes missing. Her suspicious husband becomes a quick suspect in the kidnapping but as Jess and Nicole probe into her past, they discover a shocking secret and are amazed to learn that the woman had created a new life for herself. A breathtaking climax in a strange house with a very disturbed man and his "family" reveals an unbelievable secret. Meanwhile, Jess dreams about a coffin and a wedding/funeral and has troubles with a boyfriend who has a very strange name.

A biophysicist disappears along with the only sample of a deadly virus she created. To complicate things, she claimed to have been followed by men in black suits; leading the team to wonder if the government was really survelling her or if she was going crazy. Meanwhile, Toni and Doug Mastriani come to town and when Douglas goes missing and Nicole is put on probation for a misunderstanding with Army Intelligence, Jess must balance work and family and find both missing people while she dreams about her brother in a hearst drinking beer.