It is the beginning of 'firsts' for Mindy and Danny, as they try to set new relationship boundaries for each other in the office. Meanwhile, things get a little complicated when Jeremy tries to organize a charity event with Peter's girlfriend, Lauren.

As the holidays approach, Mindy wonders if Danny is about to propose, and a case of mistaken identity leads Morgan on the perfect date.

Mindy's fertility clinic opens, but with zero track record in the fertility field, attracting new patients is tougher than she imagined. Meanwhile, at Shulman & Associates, the nurses try to raise money for obese nurses while trying to get to know Dr. Bergdahl.

Mindy’s fertility practice is in danger and Annette’s upcoming surgery looms large. While Mindy and Danny wait for word on the surgery, Mindy attends Morgan and Tamra’s dream wedding, where she and the rest of the Shulman gang try to find their own happy endings.