When Mindy goes on a date with a cute minister named Casey, she feels compelled to attend his church to show him that she is a good person. But when Casey admits to Mindy that he thinks she's a selfish person, she decides to go on the practice's volunteer trip to a women's prison to prove him wrong.

As the doctors of Schulman and Associates prepare for a medical conference in Santa Fe, NM, Mindy receives a message from her ex-boyfriend, Josh, who is now living there and wants to talk. But Mindy is in for a surprise when she discovers why Josh moved west. Meanwhile, Morgan helps Jeremy work on a potentially career-changing presentation, which doesn’t go according to plan.

When Danny's ex-wife, Christina, comes back to New York to confront Danny about an emotional letter he had written to her, Morgan confesses that he had sent the letter unbeknownst to Danny, causing Danny to fire Morgan out of anger. Meanwhile, the rest of the staff compete in a triathlon and go head-to-head with the midwives, who have hired Morgan to work for them.

Mindy acts as a mentor to a college student. But when Casey and Mindy unexpectedly hit a rough patch, she decides to drown her sorrows at a frat party where she reunites with her old flame, Tom, and all hell breaks loose. Meanwhile, Danny and Jeremy try to woo Morgan away from the midwives.

Mindy makes the bold decision to move to Haiti with Casey for a year, much to the amusement of her co-workers. In order to prove that she can survive in rough conditions, Mindy invites herself and Casey on a camping trip with Danny and his ex-wife, Christina, with whom he has recently reconciled.

Mindy and Casey's blissful time in Haiti is cut short when Mindy gets sick and is airlifted back to New York; Dr. Paul Leotard (James Franco), Schulman & Associates' new resident OB/GYN, shares sex therapy advice with Christina and Danny.

As Mindy adjusts to her long-distance relationship with Casey, she also must adjust to the fact that she is no longer the office's "Dr. L" - her office, patients and dignity have been overtaken by Dr. Paul Leotard - so she challenges Paul to get her former life back. Meanwhile, Danny has a new extracurricular activity following his breakup with Christina.

After returning from Haiti, Casey has an identity crisis and thinks being a disc jockey might be his new calling. When Mindy and the office go to a music festival for their “work retreat” to see Casey perform, the substance-filled surroundings lead to a series of disasters. Meanwhile, back in New York, Jeremy hires a new doctor, whom Mindy doesn’t particularly like after he saves the day during an emergency delivery.

According to Morgan, anyone who sleeps with him will find the love of their life immediately afterward. Curious to test this theory, Mindy takes Morgan up on his offer, but backs out at the last minute, humiliating Morgan and prompting him to sue Mindy for sexual harassment. In order to get out of the lawsuit and get back into Morgan's good graces, Mindy makes him an offer he can't refuse.

Jeremy sends Mindy, Danny, Peter and Morgan to Los Angeles to receive cosmetic injectables certification. Once they arrive, Peter attempts to track down the object of his affection, Maria Menounos, and Mindy runs into Casey.

Mindy starts to question Danny's commitment to their relationship when he's a no-show for dinner with her parents. Meanwhile, when Morgan thinks he overhears Mindy saying Danny is not the father of her baby, he gathers all the guys with whom she's ever slept, in an attempt to figure out who is the real father.

Mindy is tempted to fall back into old habits with an ex-boyfriend when Casey returns to New York.

Ben gets the opportunity to host a medical segment on a talk show, but he has no interest in fame. Mindy questions whether she wants to be with someone who doesn’t have the same ambition as her. Matters come to a head when Mindy’s bumps into an old flame.

Annette's furious when Mindy uncovers a secret about her and decides to get involved. Jody attempts to keep his new girlfriend from taking a job overseas. Tamra dives headfirst into Morgan's religion.