Mindy and Casey's blissful time in Haiti is cut short when Mindy gets sick and is airlifted back to New York; Dr. Paul Leotard (James Franco), Schulman & Associates' new resident OB/GYN, shares sex therapy advice with Christina and Danny.

As Mindy adjusts to her long-distance relationship with Casey, she also must adjust to the fact that she is no longer the office's "Dr. L" - her office, patients and dignity have been overtaken by Dr. Paul Leotard - so she challenges Paul to get her former life back. Meanwhile, Danny has a new extracurricular activity following his breakup with Christina.