Guests: Fmr Rep Harold Ford, Jr., actor/activist Sean Penn, comedian Garry Shandling; via satellite, fmr Gov Tommy Thompson and CNN's Dr. Sanjay Gupta

Topics: Republican presidential debate, State Dept terror statistics, anniversary of "Mission Accomplished" speech, "D.C. Madam" scandal, food safety, Hurricane Katrina aid

Guests: Actor Sean Penn, journalist Andrew Ross Sorkin, co-founder of the Huffington Post Arianna Huffington, director Michael Moore

Topics: Earthquakes in Haiti and Chile, Hugo Chávez, Economic activism, Health Care, the economy regulation of the financial industry, labor relations, the Oscars, Republican fundraising tactics, the Media

Huffington Post's Editor-in-Chief Arianna Huffington, "Stonewalled" author Sharyl Attkisson, The National Review's Tom Rogan, The Hunting Ground's Annie Clark & Andrea Pino and actor Sean Penn.

A heated discussion on 2016 election politics erupts among Bill and his panel guests, political journalist Peter Hamby, CNN political analyst Angela Rye, Trump economic advisor Steve Moore, and special guest actress/comedian Sarah Silverman. Bill also interviews Oscar-winning actor Sean Penn.